Replication of biocompatible, nanotopographic surfaces

Polyethylene glycol-coated biocompatible surfaces.

Surfaces covered with polyethylene glycol (PEG; HO-(CH(2)-CH(2)-O)(n)-H) have been shown to be biocompatible because PEG's properties yield nonimmunogenicity, nonantigenicity, and protein rejection. To produce a biocompatible surface coating, we have developed a method for grafting PEG onto activated silica films. We first deposited an amorphous silica film by plasma-enhanced chemical vapor dep...

Nanotopographic control of neuronal polarity.

We employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter the orientation and maturation of focal adhesions can be finely modulated yielding independent co...

Biocompatible surfaces based upon the phospholipid asymmetry of biomembranes.

Introduction The clinical application of devices or materials which come into contact with blood, for example, catheters, extracorporeal systems and dialysis membranes are of considerable importance in modern medicine. Adverse reactions between foreign or prosthetic surfaces and blood components continue to require attention. Typical examples of the need to allow for such adverse reactions are ...

Transparent, biocompatible nanostructured surfaces for cancer cell capture and culture

Circulating tumor cells (CTCs) in the blood which have detached from both the primary tumor and any metastases may be considered as a "liquid biopsy" and are expected to replace tumor biopsies in the monitoring of treatment response and determining patient prognosis. Here, we introduce a facile and efficient CTC detection material made of hydroxyapatite/chitosan (HA/CTS), which is beneficial be...

Supporting Information Switchable, Biocompatible Surfaces Based on Glycerol Copolymers